![]() Forward thinking for his time, he even described that what appeared to be horrid, smelly waste was actually the lifeblood of the people of his city and represents all aspects of humanity. Hugo also described in his novel how he believed the people of Paris did not recognize that the noxious, odiferous waste that lay in the sewers of Paris was actually representative of their actions and lives and also that smelly waste could be reused and give value to people's daily lives as manure. As the fate of Jean Valjean has ever since turned into one of Broadway's showcases, the role of sewers and drains as the “intestine of the Leviathan” and the associated smelly gas, hydrogen sulfide (H 2S), attracted public attention at that time, as did a resonance of 1777 Paris accidents in which sewer gas emission led to several fatal cases. Victor Hugo's famous 1862 French novel Les Miserables set out an unforgettable scene when the hero Jean Valjean carries the unconscious Marius toward the smelly sewers of Paris where the unrelenting Inspector Javert lays in wait. “Marge, what's wrong? Are you hungry? Sleepy? Gassy? Gassy? Is it gas? It's gas, isn't it?” Dan Castellaneta (American Actor and Writer): The Simpsons While acknowledging the challenges ahead, research on H 2S physiology and medicine is entering an exponential exploration era. Many new technologies have been developed to detect endogenous H 2S production, and novel H 2S-delivery compounds have been invented to aid therapeutic intervention of diseases related to abnormal H 2S metabolism. ![]() Alternations of H 2S metabolism lead to an array of pathological disturbances in the form of hypertension, atherosclerosis, heart failure, diabetes, cirrhosis, inflammation, sepsis, neurodegenerative disease, erectile dysfunction, and asthma, to name a few. The physiological functions of H 2S are mediated by different molecular targets, such as different ion channels and signaling proteins. The H 2S-catalyzing enzymes are differentially expressed in cardiovascular, neuronal, immune, renal, respiratory, gastrointestinal, reproductive, liver, and endocrine systems and affect the functions of these systems through the production of H 2S. It started by the discovery of endogenous H 2S production in mammalian cells and gained momentum by typifying this gasotransmitter with a variety of physiological functions. Physiological importance of H 2S has been appreciated for about a decade. Over the centuries, however, H 2S had only been known for its toxicity and environmental hazard. If you were considering Signpost, now is the time to make a move.The important life-supporting role of hydrogen sulfide (H 2S) has evolved from bacteria to plants, invertebrates, vertebrates, and finally to mammals. We are now scaling, and have a lot of huge things on the horizon. I also lead our sales council, and was peer elected social director. ![]() Over the past 2 1/2 years I have been a sales rep, sales executive, senior sales executive and account manager. There are a lot of opportunities for quick advancement and to work in different fields. I now work in Account Management learning the back end of the product. I had no prior experience and I turned out to be one of Signpost's top reps multiple times. I didn't know this going in, but I had a positive attitude the whole time, applied what was taught to me, and worked with my head down. If you're looking into sales, understand that sales is hard and that it can be an emotional soul-sucking roller coaster. The catch is that you have to understand what you're getting yourself into. ![]() If you are looking for a tech start-up to be apart of, Signpost is it. I have been with Signpost for almost 3 years.
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